Alfred G. Meyer

Alfred G. Knudson (1922–2016)

An iconic, visionary giant in medical science, Alfred G. Knudson, Jr., M.D., Ph.D. died July 10, 2016, one month short of his 94 birthday. Often referred to as the ‘‘Mendel of cancer genetics’’—Al was widely known for his groundbreaking ‘‘two-hit’’ hypothesis of cancer development and his prediction of recessiveacting tumor suppressor genes. His revolutionary two-hit hypothesis envisaged that c...

Alfred Goldberg

system, where non-sexualised images, e.g. from clothes ads or even from nudist beaches get the green light, erotic posing counts as amber, and material focusing on genitals or actual acts of child abuse gets the red light. “We train the patient to move only in the green area,” Ahlers told the paper. “Amber means: Caution! Potential danger for children and for myself! Risky behaviour on the verg...

Alfred Sheen

Alfred Adler

By Phyllis Bottome. Faber & Faber, Ltd. Price 10s. 6d. net. This is the third appreciation of Adler published in England since his death at Aberdeen in August, 1937. It is written by a well-known novelist who, with her husband, was in close touch with Adler and his family for the last ten years of his life. It is the most intimate account yet available in English and gives many personal details...

Pediatric Cancer Predisposition and Surveillance: An Overview, and a Tribute to Alfred G. Knudson Jr.

The prevalence of childhood cancer attributable to genetic predisposition was generally considered very low. However, recent reports suggest that at least 10% of pediatric cancer patients harbor a germline mutation in a cancer predisposition gene. Although some of these children will have a family history suggestive of a cancer predisposition syndrome, many others will not. Evidence from recent...